A joint report from National Association of Counties (NACo) and the National League of Cities (NLC) examines how cities and counties can strengthen collaboration with each other and state, federal, private-sector and nonprofit partners to tackle the opioid crisis. Several of the recommendations are accompanied by existing local practices from cities and counties. The report also includes recommendations for state and federal officials, who are pivotal partners in local efforts to combat opioid misuse, diversion, overdose, and death.