A growing number of law enforcement officers and first responders across the country are administering naloxone to individuals to reverse the effects of opioid overdoses. If these individuals are not subsequently and quickly connected to treatment, recovery support, and other needed resources, they are at high risk of experiencing another potentially fatal overdose. The Naloxone Plus pathway is centered on the connection of individuals to treatment and follow-up services after an opioid overdose. The emphasis in this pathway is on the Plus—administering naloxone or responding after an overdose plus the connection to treatment. Naloxone Plus is a national standard for law enforcement response in communities that have high rates of overdose.